Tachedjian et al. This unexpected finding provides insight into the actions of the inhibitors and into the dimerization process, neither of which is well understood. Therapies involving three-drug combinations are now the standard treatment for HIV-1 infections. Despite the successes with such treatments, there are still considerable problems with drug toxicity and the development of viral resistance. The approved drugs inhibit two viral enzymes: reverse transcriptase RT and protease. All of the protease inhibitors are substrate analogs; however, there are two types of RT inhibitors, nucleoside analogs and nonnucleoside inhibitors NNRTIs.
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